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Resistance and compliance are the most commonly reported outcomes when assessing lung function.
Single frequency fOT (Resistance and compliance)
In a single frequency forced oscillation manoeuvre, the subject’s response to a sinusoidal waveform is studied. The resulting pressure, flow and volume signals are fit to the single compartment model using linear regression and total respiratory system resistance, elastance and compliance are obtained.
Resistance (R): dynamic resistance quantitatively assesses the level of constriction in the lungs.
Elastance (E): elastance captures the elastic stiffness of the respiratory system at the ventilation frequency. If measured under closed-chest conditions, it includes a contribution from the lung, the chest walls, and the airways. Elastance is the reciprocal of compliance and vice versa.
Compliance (C): compliance (also known as dynamic compliance) describes the ease with which the respiratory system can be extended. In a subject with intact chest walls, it provides a characterisation of the overall elastic properties that the respiratory system needs to overcome during tidal breathing to move air in and out of the lungs.
Coefficient of determination (COD): quality control parameter measuring the quality of the single compartment model fit.